Rafael Nadal and Carlos Alcaraz will be exchanging fierce right-handers and left-handers across the net when tennis visits a legendary Las Vegas boxing venue in March.

In the lead-up to the Indian Wells Open, the Spanish superstars will go head to head at the MGM Grand Garden Arena on March 5, it was announced on Tuesday.

The indoor venue has staged major fights featuring the likes of Mike Tyson, Floyd Mayweather, Canelo Alvarez, Manny Pacquiao and Tyson Fury.

Nadal, the record 22-time men's singles grand slam winner, will be facing current world number one Alcaraz in a clash of generations. Alcaraz does not turn 20 until May, while Nadal will be 36 in June.

The match will mark Alcaraz's return to action in the United States, six months after he triumphed at the US Open in New York to land a first slam title.

Already the youngest number one in ATP history, Alcaraz is expected to win many more majors, but he recently said he turns a "deaf ear" to comparisons between himself and Nadal.

"There is no point in comparing," Alcaraz told reporters. "It doesn't matter that now I am world number one, Rafa's entire career counts for a lot. It is a pleasure, for every tennis lover, to see Rafa on the court."

The Indian Wells action begins on March 8. Nadal beat Alcaraz in last year's semi-finals before losing to Taylor Fritz in the final, later revealing he played with a broken rib in the title match.