Xavi brought Jules Kounde straight back into Barcelona's team for Sunday's Clasico clash with Real Madrid at the Santiago Bernabeu.
Kounde, a big-money signing from Sevilla, returned to training earlier this week after recovering from a hamstring issue sustained on international duty with France in September.
His return to the starting XI, which marks his Clasico debut, came at the expense of Gerard Pique, who was culpable for one of Inter's goals in Wednesday's 3-3 draw in the Champions League, which left Barca on the brink of an early exit from the competition.
Frenkie de Jong also came into the team, replacing Gavi, while Marcos Alonso made way for Alejandro Balde at left-back.
Xavi stuck with the same front three that started against Inter, with Ousmane Dembele and Raphinha flanking Robert Lewandowski, the latter two, like Kounde, making their Clasico debuts.
BARÇA XI #ElClásico pic.twitter.com/fgIDOQCuLY
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Lewandowski has scored six goals in eight meetings with Real Madrid, all in the Champions League, making him the player who has scored the most goals against Los Blancos in the history of that competition.
Sergio Busquets, meanwhile, will equal Francisco Gento (21 wins) as the player with the most victories in Clasico history in all competitions should Barca win.
Carlo Ancelotti was unable to call on goalkeeper Thibaut Courtois, who has failed to recover from injury in time to feature for the hosts, so Andriy Lunin retained his place.
Ancelotti was otherwise able to name what many would consider a first-choice XI, spearheaded by Karim Benzema, who has been involved in 20 goals in 38 Clasicos, a record only bettered by Lionel Messi in the 21st century (40).